Berrettini showed his tremendous fighting spirit, saving two championship points in captivating scenes in front of a crowd heavily in his favour.
“The isn’t the end for me, but the start of my career,” the 25-year-old Roman said after the game.
“I’m happy with this final and I hope it won’t be the last.”
Attended by the likes of Kate Middleton and Berrettini’s Australian girlfriend, Ajla Tomljanovic, the top-level tennis match came a matter of hours before Italy faced England in the highly-anticipated Euro 2020 final at Wembley Stadium.
It was Djokovic’s sixth Wimbledon men’s singles title.
The 34-year-old is now equal with Roger Federer and Rafael Nadal on 20 Grand Slam victories.