The drone was seized after the man activated it inside the World Heritage Site, despite being warned not to by staff.
Ticket staff at the entrance reportedly told the tourist that flying the drone was not allowed inside the ancient amphitheatre.
Staff then called the police when he activated it once inside, according to local media.
The man lost control of the device within seconds and it crashed into a set of steps inside the monument.
Luckily the impact did not cause any damage to the monument or any injuries.
Police charged the man with failure to comply with the no-fly zone in force in the Italian capital.