Matteo Berrettini will get things started at 11:00 am, going up against Australian wildcard Andrew Harris on Melbourne Arena.
The 23-year-old Rome native is ranked number 8 in the world.
Then young gun Jannik Sinner will head out onto Court 7 to take on Australia’s Max Purcell, who qualified for his first Grand Slam main draw on Friday.
Born in South Tyrol, 18-year-old Sinner is considered the tennis world’s next big thing.
On Court 10, Stefano Travaglia will play Chilean Cristian Garín.
Born in Ascoli Piceno, 28-year-old Travaglia reached the second round in last year’s Australian Open.
Meanwhile, Italian star Fabio Fognini will challenge American Reilly Opelka on 1573 Arena.
Hailing from Sanremo, the 32-year-old is currently ranked number 11 in the world.
This evening, Salvatore Caruso will take on Greek star Stefano Tsitsipas on Margaret Court Arena.
Born in Avola, the 27-year-old Sicilian will have his work cut out for him against Tsitsipas, who is ranked number 6 in the world and has won four singles titles and reached nine finals on the ATP Tour at just 21 years of age.
Meanwhile, Martina Trevisan is the only Italian woman to play on the first day of the tournament.
Hailing from Florence, the 26-year-old will take on America’s Sofia Kenin on Court 3 at 11:00 am.
On Tuesday, Palermo native Marco Cecchinato will keep the ball rolling, playing against German giant Alexander Zverev, who is ranked number 7 in the world.
Torinese player Lorenzo Sonego will also take to the court on Day 2, to battle it out against Australia’s Nick Gyrgios, who is ranked number 26 in the world.
Meanwhile, Bolzano-born Andreas Seppi will go up against Serbia’s Miomir Kecmanović.
In the women’s, Elisabetta Cocciaretto and Camila Giorgi will take on German players Angelique Kerber and Antonia Lottner respectively.
Camila Giorgi
This will be 18-year-old Ancona native Cocciaretto’s first Grand Slam.
Meanwhile, Macerata-born Giorgi made it to the third round in last year’s tournament.
Also on Tuesday, Tuscan player Jasmine Paolini will play Russia’s Anna Blinkova.