A further 431 fatalities were recorded on Wednesday.
The country’s death toll from the pandemic now stands at 103,432, according to the official data from the health ministry.
This is the highest tally in the European Union and the second-highest in Europe after the UK.
The total number of infections in the country since the beginning of the pandemic is more than 3.2 million.
The latest figures come as much of Italy entered a strict lockdown on Monday to counter a spike in infections.
The nine regions that are designated high-risk “red zones” – including Lazio, surrounding Rome – will remain locked down until at least April 6.
They will be joined by the rest of the country over the Easter holidays from April 3 to 5, in a bid to prevent the usual large family gatherings.
A slowdown in delivery of vaccines by manufacturers and other logistics problems had hindered Italy’s vaccine rollout, but the pace of injections has improved in recent days.
More than 7 million doses have so far been administered across Italy and 2.1 million people have been fully vaccinated.
On Monday, Italy joined several other European nations in temporarily suspending the use of the AstraZeneca vaccine over reports of blood clotting.
The European Medicines Agency (EMA) is investigating whether there is a link between the AstraZeneca vaccine and blood clotting but reiterated on Tuesday that the rate of blood clots reported in vaccinated people “does not seem to be higher that than seen in the general population”.
“[We are] firmly convinced that the benefits of the AstraZeneca vaccine in preventing COVID-19, with its associated risk of hospitalisation and death, outweigh the risks of side effects,” Emer Cooke, executive director of the EMA, said.
