Victor Osimhen scored a double, Khvicha Kvaratskhelia converted a penalty and Tanguy Ndombele was also on target to put Napoli on 71 points from 27 games.
Both Osimhen’s goals were headers, one from a corner and the other from a cross during open play.
Ndombele’s goal was the result of a cut back in the box from Kvaratskhelia that the Frenchman slotted home through the legs of Vanja Milinkovic-Savic.
After Inter Milan’s loss to Juventus, Napoli are now five wins from sealing the title.
Should second place Lazio lose one of their next four games, the title race could be over even sooner.
