The letter was written to his sister before his capture by police.
"I will not die of cancer, as soon as I cannot take it anymore, I will kill myself at home and you will find me,” it read.
“I will tell you when the time comes."
Denaro was captured at a Palermo cancer clinic in January after 30 years on the run.
The Trapani boss had been condemned to life in prison in absentia for his involvement in dozens of murders.
These included the 1992 bombings that killed anti-Mafia magistrates Giovanni Falcone and Paolo Borsellino, the killing of Giuseppe Di Matteo, the 12-year-old son of a mobster-turned-State witness who was strangled and dissolved in acid in 1996, and bombings at art and religious sites in Milan, Florence and Rome that killed 10 people and injured 40 more in 1993.
He is now being held at a maximum-security prison in L'Aquila.
Rosalia Denaro was arrested in March on charges of mafia association for allegedly helping her brother evade capture and acting on his behalf as the 'cashier' of the 'family'.
It is also believed she was the conduit through which Denaro’s 'pizzini' (little messages) spread, thus enabling the mafia boss to maintain relations with his men during his long period as a fugitive from justice.
ANSA