Possession was equal with the visitors creating more chances, 14 to Napoli’s eight.
Napoli took the lead in under nine minutes thanks to an own goal by Serdar Saatci, whose trailing leg was struck by Matteo Politano’s cross before going in off the cross bar despite the best efforts of goalkeeper Matheus Magalhaes.
The Neapolitans doubled their lead in the 33rd minute when Victor Osimhen finished Natan’s square pass inside the box with a backheel that bounced over the keeper.
Napoli finish second in their group behind Real Madrid, with the draw for the next round to occur on December 18.