Juventus moved three points above Inter Milan on Sunday and eight ahead of fifth-place AC Milan, with three rounds remaining.
Cremonese are six points from safety.
Pogba was making his first start for Juve since his move back from Manchester United in the off-season but limped off the field in the 22nd minute, to the applause of fans in the stadium.
The French international fell to the ground clutching his left leg after kicking a ball with his right leg. He could be seen crying as he pulled his shirt over his face.
The 30-year-old was making his first start since last April. He has made just nine substitute appearances since returning to Turin.
He is almost certainly out of the second leg of Juve's Europa League semi-final against Sevilla on Thursday with the score currently at 1-1.
After Pogba went off, there were few chances before Nicolo Fagioli broke the deadlock 15 minutes into the second half. Fagioli did not celebrate against his former team.
Bremer headed in the second 11 minutes from time.
AAP