Italian Interior Minister Matteo Salvini and Rome Mayor Virginia Raggi were at the scene as more than 600 police took over the opulent Casamonica clan villas and smashed their way in.
As the walls crumbled there were shouts from the villas’ residents, and around 30 people were evicted.
Those evicted claimed they had been given no warning and had nowhere to take their children.
A lawyer for the Casamonicas told Italian media he would be challenging the demolition order.
The Casamonica clan was one of the alleged crime networks accused of infiltrating the city’s government and influencing politicians in a large-scale corruption investigation in 2015.