After Nicolo Barella's opener for Inter, Fredrik Aursnes restored some hope for Benfica shortly before halftime. 

But Lautaro Martinez and substitute Joaquin Correa netted in the second half to help Inter reach their first semi-final since Jose Mourinho led them to the treble of the Champions League, Serie A and Italian Cup in 2010.

Antonio Silva and Petar Musa netted late on for Benfica but it was not enough to deny Inter a derby date with city rivals AC Milan in the last-four. 

“I am happy for the boys because it is an important and historic achievement,” Inter coach Simone Inzaghi said. 

“We've come a long way from a very, very difficult group.”

The first legs of both semi-finals are scheduled for May 8 (May 9 AEST). 

AAP