The announcement comes just over a week after Conte delivered a post-match rant in which he accused the team's players of being "selfish" and also took aim at the club's ownership.

"We have 10 Premier League games remaining and we have a fight on our hands for a Champions League place," Tottenham chairman Daniel Levy said in a club statement released Sunday night.

"We all need to pull together. Everyone has to step up to ensure the highest possible finish for our Club and amazing, loyal supporters."

From dominating Italian soccer as a player and being regarded as one of the best coaches in the world, to match fixing scandals and lawsuits, Conte has enjoyed a chequered managerial career.

Stints with Chelsea, Juventus and the Italian national team have seen him establish himself as one of European soccer's leading coaches.

A recent highlight was helming Inter Milan to the Serie A title in 2020/21 before taking up his most recent role at Spurs.

Conte was in charge of Tottenham for 16 months but was unable to end their trophy drought stretching back to 2008.

His tenure ended in an undignified way, with his outburst after the 3-3 draw at Southampton making his departure almost inevitable. His contract was due to expire at the end of the season.

The 53-year-old Conte tore into his players for what he perceived to be a poor attitude, accusing them of not playing as a team and failing to deal with pressure, before saying: "20 years there is the (same) owner and they never won something."

After days of speculation about his future, Tottenham confirmed his exit.

"We can announce that head coach Antonio Conte has left the Club by mutual agreement," the London club said in a statement.

"We achieved Champions League qualification in Antonio's first season at the Club. We thank Antonio for his contribution and wish him well for the future."

Conte leaves with Tottenham out of the Champions League and FA Cup, ensuring they will not win any silverware this season. But the team is in fourth place in the league and in contention to qualify for the Champions League again next season.

Tottenham appointed former Chelsea manager Conte as the replacement for Nuno Espirito Santo in November 2021, with the club in eighth place. He succeeded in guiding Spurs to a top-four finish.

Tottenham spent about US$140 million (A$210.5 million) since his arrival, including US$73.5m (A$110.5m) on Brazil forward Richarlison. The most recent signing was Pedro Porro, a wing back bought because he suits Conte's ideal 3-4-3 formation.

Conte had just returned to the touchline after recovering from gallbladder surgery and also has had to contend with personal trauma following the deaths of three close friends over the past five months - Tottenham fitness coach Gian Piero Ventrone, and former players Sinisa Mihajlovic and Gianluca Vialli.

His outburst after Southampton was surprising even for a manager who has developed a reputation for being fiery.

"They don't want to play under pressure. They don't want to play under stress," he said.

Some interpreted it as evidence he wanted to go.

"Conte wants to be sacked (fired) in this international break," English TV commentator Jamie Carragher wrote on Twitter at the time. "Spurs should just put him out of his misery and do it tonight."

Stellini led Tottenham's first team while Conte was recovering from his recent surgery, which included the loss to second-tier Sheffield United in the FA Cup.

Ryan Mason has been appointed as assistant head coach.

AAP