Binotto, 53, will leave his post on December 31 following four years at the helm of the Italian team.
Ferrari finished second in the constructors’ championship, while Charles Leclerc ended the year as runner-up to Red Bull’s Max Verstappen in the drivers’ standings.
But Binotto is moving on following a catalogue of Ferrari errors which dented Leclerc’s charge for the title.
Binotto has been with Ferrari for 28 years and took over the team principal role in 2019.
The team was winless in 2020 and 2021, but started 2022 promisingly as Charles Leclerc won two of the opening three races, only for his title challenge to fizzle out.
A botched pit stop at the Dutch Grand Prix in September saw only three tyres initially fitted to Carlos Sainz Jr.’s car, and was seen as a symbol of Ferrari’s difficulties.
“With the regret that this entails, I have decided to conclude my collaboration with Ferrari,” said Binotto.
“I am leaving a company that I love, which I have been part of for 28 years, with the serenity that comes from the conviction that I have made every effort to achieve the objectives set.
“I leave a united and growing team. A strong team, ready, I’m sure, to achieve the highest goals, to which I wish all the best for the future. I think it is right to take this step at this time as hard as this decision has been for me.
“I would like to thank all the people at the Gestione Sportiva who have shared this journey with me, made up of difficulties but also of great satisfaction.”
Ferrari did not immediately name a successor but said its choice “is expected to be finalised in the New Year.”
― With AAP.