The 45-year-old was last heard from by his family on May 16.
Investigators believe Ciano may be travelling in a brown Mitsubishi Triton with registration FLY WHL and may be in the Kilmore area.
Police and family hold concerns for Ciano’s welfare due to a medical condition.
Police have released images of Ciano and his car in the hope someone may recognise him and provide information regarding his current whereabouts.
Anyone who sights Flavio or the Triton is urged to contact Craigieburn Police Station on (03) 9303 4433.