“This Easter you could make a significant dent in those figures if you don’t do the right thing,” she said.
“Most Victorians are doing the right thing.
“Stay at home, stay at your primary residence.”
While Neville said people can legally visit their holiday homes, she urged Victorians not to head to regional and coastal communities.
It comes as the total number of coronavirus cases in Victoria jumped to 1228 overnight, an increase of 16 from Wednesday.
There are 50 people are in hospital, including 13 patients in intensive care, and 806 people have recovered.
Of the total 1228 cases, there have been 992 in Melbourne and 225 in regional Victoria.
Several cases are still being investigated.
There were no new deaths overnight.
The number of people who have died in Victoria from coronavirus is 12.