This is the club’s second coaching change this season.
On Monday, Davide Nicola, who helped Crotone and Salernitana avoid relegation in recent seasons, was hired to replace Andreazzoli.
Nicola was given a contract through the end of the season with an option for next season.
The move came two days after Empoli lost 2-1 at Hellas Verona, another club in the drop zone.
The Tuscan team have won just three of 20 matches.
The 70-year-old Andreazzoli had signed a one-year contract with Empoli in September to replace Paolo Zanetti.
It’s the fifth coaching change in the Italian league this season.
AAP