Medvedev is now the hottest player on the men's tour, winning 24 of his last 25 matches after racing to victory in one hour and 34 minutes on Sunday.
His only loss has come against top-ranked Carlos Alcaraz in the Indian Wells final.
He's made five straight finals and believes this run compares to his 2019 streak, when he advanced to the championship round in six straight events.
"It's kind of the same,'' Medvedev said.
"It's the best start to a season I've ever had. It's been an amazing amount of (ATP points) won. I'm super happy.''
Sinner ran out of magic, with his three-hour win late Friday night over Alcaraz in the semi-finals – when he suffered mild cramping in the second set – taking a toll on the 21-year-old.
Sinner was visited by an ATP trainer midway through the first set. During the changeover at 4-3, Sinner received a packet of salt that he dumped into a water bottle to drink.
In his post-match press conference, Sinner said he didn't "wake up in the best possible way'' but didn't specify the illness.
"We tried to go out on the court, trying to give it a try,'' Sinner said.
"Unfortunately today wasn't my day but I don't want to take nothing away from Daniil.
"He was serving incredible. He was very brave with the way he played. He's one of the best players in the world.''
Sinner said the trainer's salt didn't make a huge difference.
"It helped me a little bit but not enough,'' Sinner said. "When you wake up like this, there's not magical things.''
Serving 5-6 in the first set, Sinner didn't have any dazzle left and played a ragged game as Medvedev broke him to close out the first set.
At 15-30, Sinner shanked a backhand that went long, then fired a forehand bullet into the top of the net to end the one-hour first set.
Sinner said he may have had "a little bit'' of a mental letdown off the Alcaraz win but noted he was also facing an opponent he had never beaten.
"I was very looking forward to it and prepared a lot,'' Sinner said.
"It was a very good win. But I was focused on Daniil because I've never won.''
While Medvedev has won titles this year in Rotterdam, Doha and Dubai, this is the Russian's first title on American soil since the 2021 US Open, when he derailed Novak Djokovic's bid for a 'Grand Slam' (the accomplishment of winning all four major championships in the same calendar season).
Medvedev has proven to be the master of the hardcourt, but the tour turns to the European clay court season.
"I love the hardcourts. If it would be my choice, it would be only hardcourts. I wish all the tournaments were hardcourt.''
AAP